Publications | Yardeni Lab

2024

Gross G, Alkadieri S, Meir A, Itzhaki O, Aharony-Tevet Y, Ben Yosef S, Zenab A, Shbiro L, Toren A, Yardeni T, Jacoby E. 2024. Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose. Leukemia. https://doi.org/10.1038/s41375-024-02257-z

2022

Schaefer PM, Huang J, Butic A, Perry C, Yardeni T, Tan W, Morrow R, Baur JA, Wallace DC. 2022. Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice. Mol Metab. doi: 10.1016/j.molmet.2022.101560.

Schaefer PM, Scherer Alves L, Lvova M, Huang J, Rathi K, Janssen K, Butic A, Yardeni T, Morrow R, Lott M, Murdock D, Song A, Keller K, Garcia BA, Francomano CA, Wallace DC. 2022. Combination of common mtDNA variants results in mitochondrial dysfunction and a connective tissue dysregulation. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2212417119.

2021

Yardeni T, Cristancho AG, McCoy A, Schaefer PM, McManus MJ, Marsh ED, and Wallace DC. 2021. An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proceedings of the National Academy of Sciences Feb 2021, 118 (6) e2021429118; DOI: 10.1073/pnas.2021429118.

Kozicz T, Morava E, Yardeni T. 2021. Powering the brain in health and disease. Eur J Neurosci. doi: 10.1111/ejn.15230.

2019

Huizing M, Yardeni T, Fuentes F, Malicdan MCV, Leoyklang P, Volkov A, Dekel B, Brede E, Blake J, Powell A, Chatrathi H, Anikster Y, Nuria Carrillo N, Gahl WA, Kopp JB. 2019. Rationale and Design for a Phase 1 Study of N-Acetylmannosamine for Primary Glomerular Diseases. Kidney International Reports; doi: 10.1016/j.ekir.2019.06.012

Yardeni T, Tanes CE, Bittinger K, Mattei LM, Schaefer PM, Singh LN, Wu GD, Murdock DG, Wallace DC. 2019. Host mitochondria influence gut microbiome diversity: A role for ROS. Sci Signal; doi: 10.1126/scisignal.aaw3159.

2018

Yardeni T, Fine R, Joshi Y, Gradus-Pery T, Kozer N, Reichenstein I, Yanowski E, Katz S, Weiss H, Eisenberg M, Shalit T, Plotnikov A, Barr H.M, Perlson E and Hornstein E. 2018. High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria. Sci Rep; Jan 8;8(1):59.

2017

Barel O, Christine V Malicdan M, Ben-Zeev B, Kandel J, Pri-Chen H, Stephen J, Castro IG, Metz J, Atawa O, Moshkovitz S, Ganelin E, Barshack I, Polak-Charcon S, Nass D, Marek-Yagel D, Amariglio N, Shalva N, Vilboux T, Ferreira C, Pode-Shakked B, Heimer G, Hoffmann C, Yardeni T, Nissenkorn A, Avivi C, Eyal E, Kol N, Glick Saar E, Wallace DC, Gahl WA, Rechavi G, Schrader M, Eckmann DM, Anikster Y. 2017. Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy. Brain; 1;140(3):568-581.

Malicdan MCV, Vilboux T, Ben-Zeev B, Guo J, Eliyahu A, Pode-Shakked B, Dori A, Kakani S, Chandrasekharappa SC, Ferreira C, Shelestovich N, Marek-Yagel D, Pri-Chen H, Blatt I, Niederhuber JE, He L, Toro C, Taylor RW, Deeken J, Yardeni T, Wallace DC, Gahl WA, Anikster Y. 2017. A novel inborn error of the Coenzyme Q10 biosynthesis pathway: Cerebellar ataxia and static encephalomyopathy due to COQ5 C-Methyltransferase deficiency. Hum Mutat; doi: 10.1002/humu.23345.

2016

Yardeni T and Hornstein E. 2016. Protocol for high content screening for the impact of overexpressed microRNAs on primary motor neurons. MicroRNA Technologies pp 11-19, Neuromethods.

2015

Hinderlich S, Weidemann W, Yardeni T, Horstkorte R, Huizing M. 2015. UDP-GlcNAc 2-epimerase/ManNAc kinase, a master regulator of sialic acid synthesis. Top Curr Chem; 366:97-137. doi: 10.1007/128_2013_464.

2014

Leoyklang P, Malicdan MC, Yardeni T, Celeste F, Ciccone C, Li X, Jiang R, Gahl WA, Carrillo-Carrasco N, He M, Huizing M. 2014. Sialylation of Thomsen-Friedenreich antigen is a noninvasive blood-based biomarker for GNE myopathy. Biomark Med; 8(5):641-52.

2013

Patzel KA, Yardeni T, Le Poëc-Celic E, Leoyklang P, Dorward H, Alonzi DS, Kukushkin NV, Xu B, Zhang Y, Sollogoub M, Blériot Y, Gahl WA, Huizing M, Butters TD. 2013. Non-specific accumulation of glycosphingolipids in GNE myopathy. J Inherit Metab Dis; doi: 10.1007/s10545-013-9655-6.

2012

Kakani S*, Yardeni T*, Poling S, Ciccone C, Vincent L, Dorward H, Patzel K, Klootwijk R, Manoli I, Darvish D, Hoogstraten-Miller S, Zerfas P, Tian E, Ten Hagen K, Kopp JB, Gahl WA, Huizing M. 2012. The Gne M712T mouse as a model for human glomerulopathy. [*co-first author]. Am J Pathol; Apr;180(4):1431-40. doi: 10.1016/j.ajpath.2011.12.023.

Niethamer TK, Yardeni T, Leoyklang P, Ciccone C, Astiz-Martinez A, Jacobs K, Dorward HM, Zerfas PM, Gahl WA, Huizing M. 2012. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Molecular Genetics and Metabolism; 107(4):748-55.

Yardeni T, Ciccone C, Anikster Y, Kurochkina N, Gahl WA, Huizing M. 2012. Murine isoforms of UDP-GlcNAc 2-epimerase/ManNAc kinase: Secondary structures, expression profiles, and response to ManNAc therapy. Glycoconjugate Journal; doi: 10.1007/s10719-012-9459-1.

2011

Yardeni T, Eckhaus M, Huizing M, Hoogstraten-Miller S. 2011. Retro-Orbital Injections in Mice. Laboratory Animals; 40:155-60.

Yardeni T, Ciccone C, Patzel K, Anikster Y, Kurochkina N, Gahl WA, Huizing M. 2011. Identification, Tissue Distribution and Molecular Modeling of Novel Human Isoforms of the Key Enzyme in Sialic Acid Synthesis, UDP-GlcNAc 2-epimerase/ManNAc Kinase. Biochemistry; 18;50 (41):8914-25.

Nemunaitis G, Jay CM, Maples PB, Gahl WA, Huizing M, Yardeni T, Tong AW, Phadke AP, Pappen BO, Bedell C, Allen H, Hernandez C, Templeton NS, Kuhn J, Senzer N, Nemunaitis J. 2011. Hereditary Inclusion Body Myopathy (HIBM): Single Patient Response to Intravenous Dosing of GNE Gene Lipoplex. Human Gene Therapy;

2010

Shapiro R*, Anikster Y*, Yardeni T*, Korem S, Hartman K, Shamir R, Broide E, Levine A, Bujanover Y, Bercovich D. 2010. DHPLC screening for mutations in progressive familial intrahepatic cholestasis patients. Journal of Human Genetics; 55: 308-313.

Kurochkina N, Yardeni T, Huizing M. 2010. Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effects of mutations associated with HIBM and sialuria. Glycobiology; 20: 322-337.

2008

Bercovich D, Elimelech A, Yardeni T, Korem S, Zlotogora J, Gal N, Goldstein N, Vilensky B, Segev R, Avraham S, Loewenthal R, Schwartz G, Anikster Y. 2008. Genotype-phenotype correlations analysis of mutations in the phenylalanine hydroxylase (PAH) gene. Annals of Human Genetics; 72(Pt 3): 305-309.

Bercovich D, Elimelech A, Zlotogora J, Korem S, Yardeni T, Gal N, Goldstein N, Vilensky B, Segev R, Avraham S, Loewenthal R, Schwartz G, Anikster Y. 2008. A Mutation Analysis of the Phenylalanine Hydroxylase (PAH) Gene in the Israeli Population. Journal of Human Genetics; 53: 407-418.

Yardeni Mitochondrial Research Lab